Ketomac Shampoo contains Ketoconazole, a broad-spectrum synthetic antifungal agent in a concentration of 2% in an aqueous suspension.

MECHANISM OF ACTION: Ketoconazole works by killing fungi on skin called Malassezia. These fungi occur naturally on the skin, however, people suffering from dandruff seem to have more of Malassezia. It works by interfering with the synthesis of ergosterol, a vital component of fungal cell membranes, thereby weakening it. The weakened cell membrane allows the contents of the fungal cell to leak out resulting in its death.



Ketomac Cream is an antifungal medication that prevents fungus from growing on your skin. It is used to treat fungal and yeast infections of the skin.

Ketoconazole kills fungi and yeasts by interfering with their cell membranes. It works by impairing the synthesis of ergosterol, which is an essential component of fungal cell membranes. The disruption in production of ergosterol causes holes to appear in the fungal cell membrane.

The cell membranes of fungi are vital for their survival. They keep unwanted substances from entering the cells and stop the contents of the cells from leaking out. As ketoconazole causes holes to appear in the cell membranes, essential constituents of the fungal cells leak out. This kills the fungi and clears up the infection.



Ketoconazole is an effective, broad-spectrum, systemic antifungal agent. Ketomac tablets containing Ketoconazole 200 mg for oral administration.

Ketoconazole blocks the synthesis of ergosterol, a key component of the fungal cell membrane, through the inhibition of cytochrome P-450 dependent enzyme lanosterol 14?-demethylase responsible for the conversion of lanosterol to ergosterol in the fungal cell membrane. This results in an accumulation of methylated sterol precursors and a depletion of ergosterol within the cell membrane thus weakening the structure and function of the fungal cell membrane.