Ketomac Tablet

Ketoconazole is an effective, broad-spectrum, systemic antifungal agent. Ketomac tablets containing Ketoconazole 200 mg for oral administration.

Mechanism Of Action

Ketoconazole blocks the synthesis of ergosterol, a key component of the fungal cell membrane, through the inhibition of cytochrome P-450 dependent enzyme lanosterol 14 Alpha -demethylase responsible for the conversion of lanosterol to ergosterol in the fungal cell membrane. This results in an accumulation of methylated sterol precursors and a depletion of ergosterol within the cell membrane, thus weakening the structure and function of the fungal cell membrane.


Ketoconazole Tablets should be used when other effective antifungal therapy is unavailable or tolerated, and the potential benefits are considered potential risks. Ketomac (Ketoconazole) Tablets are indicated for treating systemic fungal infections in patients who have failed or are intolerant to other therapies: blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis.


Substrates such as dofetilide, quinidine, cisapride and pimozide are contraindicated with Ketoconazole Tablets.

Side Effects: Mild nausea, vomiting or stomach pain, mild itching, skin rash, headache and dizziness.

Dosage: As directed by the physician.

Storage: Store in a cool & dry place. Protect from light.

Presentation: 10 x 10 Tablets